Expression of the MAGE-1,-3 Genes in Squamous Cell Carcimomas of the Head and Neck

Lee, Kang Dae; Lee, Kil Soo; Lee, Bong Hee; Lee, Yun-Woo; Lee, Han Kook; Yu, Tae Hyun; Kim, Kwang Huck

doi:10.35420/jcohns.1997.8.2.287

J Clin Otolaryngol Head Neck Surg 1997; 8(2):287-292

pISSN: 1225-0244, eISSN: 2713-833X

DOI: https://doi.org/10.35420/jcohns.1997.8.2.287

원저

두경부 편평상피세포암종에서의 MAGE-1,-3 Gene의 발현

이강대¹, 이길수¹, 이봉희¹, 이윤우¹, 이한국¹, 유태현¹, 김광혁¹

Expression of the MAGE-1,-3 Genes in Squamous Cell Carcimomas of the Head and Neck

Kang Dae Lee¹, Kil Soo Lee¹, Bong Hee Lee¹, Yun-Woo Lee¹, Han Kook Lee¹, Tae Hyun Yu¹, Kwang Huck Kim¹

Author Information & Copyright ▼

¹고신의대 이비인후과학 교실，미생물학 교실

¹Department of Otolaryngology & Microbiology, College of Medicine, Kosin University, Pusan, Korea

© Copyright 1997 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: May 31, 2020

ABSTRACT

The MAGE genes encode tumor antigens recognized by cytotoxic T lymphocytes. These antigens may constitute useful targets for anti-cancer immunotherapy, since no expression of MAGE genes has been observed in normal tissues except testis.

We investigated the expression of the MAGE-1, and -3 genes in 25 squamous cell carcinomas, 10 benign tumors, and 15 normal tissues of head and neck, using reverse transcription polymerase chain reaction (RT—PCR). The MAGE-1, and -3 genes were expressed at the mRNA level in 32%(8/25), 48%(12/25) respectively. Sixteen out of 25 cases(64%) expressed at least one of these genes. Neither benign tumors nor normal tissues was positive for these genes. These results suggest that immunotherapy with MAGE gene products may be useful for patients with squamous cell carcinoma of head and neck.

Keywords: MAGE genes; RT-PCR; Immunotherapy