Sudden Sensorineural Hearing Loss after Granulocyte-Colony Stimulating Factor Administration

Kim, Seon-Lin; Oh, Se-Joon; Kong, Soo-Keun; Goh, Eui-Kyung

doi:10.35420/jcohns.2018.29.1.87

J Clin Otolaryngol Head Neck Surg 2018; 29(1):87-90

pISSN: 1225-0244, eISSN: 2713-833X

DOI: https://doi.org/10.35420/jcohns.2018.29.1.87

증례

Granulocyte-Colony Stimulating Factor 투여 후 발생한 돌발성 난청

김선린¹, 오세준¹, 공수근¹, 고의경¹^,^*

Sudden Sensorineural Hearing Loss after Granulocyte-Colony Stimulating Factor Administration

Seon-Lin Kim¹, Se-Joon Oh¹, Soo-Keun Kong¹, Eui-Kyung Goh¹^,^*

Author Information & Copyright ▼

¹부산대학교 의과대학 이비인후과학교실

¹Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University College of Medicine and Medical Research Institute, Busan, Korea

^*교신저자: 고의경, 49241 부산광역시 서구 구덕로 179 부산대학교 의과대학 이비인후과학교실 전화: (051) 240-7335·전송: (051) 246-8668 E-mail: gohek@pusan.ac.kr

© Copyright 2018 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Mar 22, 2018; Revised: Apr 25, 2018; Accepted: May 24, 2018

Published Online: May 31, 2020

ABSTRACT

Filgrastim^® (Granulocyte-colony stimulating factor, G-CSF) is generally used to promote the increase of neutrophils to patients with neutropenia during chemotherapy or donors for hematopoietic stem cell transplantation (HSCT). Its adverse effects were mainly reported as non-serious symptoms, such as back pain, headache, arthralgia and fever. A 29-year-old male was administered the Filgrastim as a HSCT donor. He accompanied left side hearing disturbance and tinnitus after 2 days from administration of the drug. He admitted to our department and underwent improvement of hearing after high dose steroid therapy. In this report, we describe a case of sudden sensorineural hearing loss (SSNHL) as an unreported adverse effect of G-CSF in the literature. (J Clinical Otolaryngol 2018;29:87-90)

Keywords: 과립구 세포군 촉진인자; 호중구림프구 비; 돌발성 난청

Keywords: Filgrastim; Neutrophil-to-lymphocyte ratio; Sudden sensorineural hearing loss; Granulocyte-colony stimulating factor