Table 7. Expression of Wnt signaling pathway proteins in each grade of IP

Markers IHC grade IP Grade Total Spearman’s ρ p-value
I (n=28) II (n=37) III (n=37) IV (n=13)
Wnt-1 0 0 0 0 0 0 0.142 0.130
1+ 12 21 9 6 48
2+ 12 16 26 2 56
3+ 4 0 2 5 11
β-Catenin 0 8 1 1 2 12 0.427 <0.001
1+ 11 16 6 1 34
2+ 9 19 20 8 56
3+ 0 1 10 2 13
Cyclin D1 0 0 0 0 0 0 0.355 <0.001
1+ 11 6 5 1 23
2+ 16 25 22 6 69
3+ 1 6 10 6 23
Dvl-1 0 7 11 0 2 20 0.380 <0.001
1+ 14 18 15 3 50
2+ 7 8 17 5 37
3+ 0 0 5 3 8
Adopted from Jung et al.18) with permission of Sage.