Table 6. Expression of p53, COX-2, bax, bcl-2, and NF-κB and their relationship with histologic grades

			No. of tissue cores(%), Total (n=80)				CC
			Grade I (n=32)	Grade II (n=37)	Grade III (n=6)	Grade IV (n=5)
COX-2	N		29 (90.6)	30 (81.1)	2 (33.3)	1 (20.0)	0.456*
	P		3 (9.4)	7 (18.9)	4 (66.7)	4 (80.0)
		1+	3	7	0	1
		2+	0	0	1	2
		3+	0	0	3	1
p53	N		32 (100)	37 (100)	0 (0)	0 (0)	0.798*
	P		0 (0)	0 (0)	6 (100)	5 (100)
		1+	0	0	1	1
		2+	0	0	3	0
		3+	0	0	2	4
bax	N		22 (66.8)	31 (83.8)	3 (50.0)	1 (20.0)	0.187
	P		10 (33.2)	6 (16.2)	3 (50.0)	4 (80.0)
		1+	2	3	0	1
		2+	8	3	0	2
		3+	0	0	3	1
bcl-2	N		32 (100)	37 (100)	5 (83.3)	4 (80.0)	0.163
	P		0 (0)	0 (0)	1 (16.7)	1 (20.0)
		1+	0	0	0	0
		2+	0	0	0	0
		3+	0	0	1	1
NF-κB	N		18 (56.3)	21 (56.8)	3 (50.0)	2 (40.0)	0.067
	P		14 (43.7)	16 (43.2)	3 (50.0)	3 (60.0)

p<0.05.
Adopted from Yoon et al.¹⁶⁾ with permission of Elsevier.
N: indicates negative; P: positive; CC: Spearsman rank correlation coefficiency; n: number of tissue cores.