Aspirin 복용 후 발생한 양측성 돌발성 감각 신경성 난청 1예

Aspirin causes ototoxic side effects in some patients, such as bilateral mild to moderate sensorineural hearing loss and tinnitus, dizziness although its ototoxic mechanisms still remain mostly unclear. Generally, ototoxicity of the aspirin manifests bilateral sensorineural hearing loss that shows flat type or high-frequency type and sometimes accompanies dizziness, tinnitus, and ear fullness. The risk of ototoxicity increases with higher aspirin doses and prolonged treatment course. We report a case of sudden sensorineural hearing loss and dizziness and tinnitus after six hours with ordinary therapeutic dose of aspirin. The patient complained of bilateral tinnitus, ear fullness, and continuous dizziness for several hours with nausea and vomiting. In this case, the patient stopped taking the aspirin and there was a hearing improvement after three days. On five days after stopping taking the aspirin, both ear audiogram was checked within the normal hearing threshold. (J Clinical Otolaryngol 2010; 21:67–70)