Journal of Clinical Otolaryngology Head and Neck Surgery

The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery

J Clin Otolaryngol Head Neck Surg 2002; 13(2):188-198

pISSN: 1225-0244, eISSN: 2713-833X

DOI: https://doi.org/10.35420/jcohns.2002.13.2.188

원저

중이진주종과 고막 경계부에서 Heat-Shock Protein 60 및 70의 발현

이윤우¹^,^*, 전경명², 왕수건², 고의경², 노환중², 천봉권³, 유태현¹, 이강대¹, 이봉희¹, 이한국¹, 손성환¹

Expression of Heat-Shock Protein 60 and 70 in the Junction between Cholesteatoma and Ear Drum

Yun-Woo Lee¹^,^*, Kyong-Myong Chon², Soo-Geun Wang², Eui-Kyung Goh², Hwan-Jung Roh², Bong Kwon Chun³, Tai Hyun Yu¹, Kang Dae Lee¹, Bong Hee Lee¹, Han Kook Lee¹, Seong Hwan Son¹

¹고신대학교 의과대학 이비인후과학교실

²부산대학교 의과대학 이비인후과학교실

³병리학교실

¹Department of Otolaryngology, College of Medicine, Kosin University, Busan, Korea

²Pathology, College of Medicine, Kosin University, Busan, Korea

³Department of Otolaryngology, College of Medicine, Busan National University, Busan, Korea

^*교신저자: 이윤우, 602-702 부산광역시 서구 암남동 34 고신대학교 의과대학 이비인후과학교실 전화： (051) 990-6726·전송： (051) 245-8935 E-mail： ynwlee@ns.kosinmed.or.kr

© Copyright 2002 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Sep 13, 2002; Accepted: Oct 29, 2002

Published Online: May 31, 2020

ABSTRACT

Background and Objectives: Pathogenesis of cholesteatoma is characterized by cellular proliferation, differentiation, and programmed cell death of keratinizing epithelium in the middle ear cavity. This study was performed to investigate the role of Heat-shock protein 60 and 70 (HSP60 and 70) in the pathogenesis of cholesteatoma. Materials and Methods: Cholesteatoma samples were taken from 7 patients during operation. Immunohistochemical stain was used for HSP 60 and HSP 70. External ear canal skin and ear drum were used as a control group. Results: HSP60 is detected in all cases and HSP 70 is detected in 5 cases in all layers of cholesteatoma epithelium from the junction between drum and cholesteatoma. HSP60 and HSP70 are not detected in the skin of external ear canal and ear drum. Conclusion: HSP60 and HSP70 may have integral role in the pathogenesis of acquired cholesteatoma and we suggest abnormal hyperplasia of epithelial cells as a pathogenesis of acquired cholesteatoma. (J Clinical Otolaryngol 2002;13:188–198)

Keywords: 진주종; Heat-shock proteins; 과형성; 세포고사

Keywords: Cholesteatoma; Heat-shock proteins; Hyperplasia; Apoptosis